Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity
نویسندگان
چکیده
منابع مشابه
Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity
Emerging clinical and preclinical evidence suggests that a compound displaying high affinity for μ, κ, and δ opioid (MOP, KOP, and DOP) receptors and antagonist activity at each, coupled with moderate affinity and efficacy at nociceptin opioid peptide (NOP) receptors will have utility as a relapse prevention agent for multiple types of drug abuse. Members of the orvinol family of opioid ligands...
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Opiates have been the most widely investigated class of natural products.1 The two most prominent opiates, morphine and codeine, have had a long history of use and abuse. Numerous semisynthetic opiates have been synthesized in an effort to obtain analgesics that are free of tolerance, physical dependence, and addiction liability. The development of totally synthetic analgesics subsequently led ...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2014
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm401964y